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Project: Gaussian splatting for the 3D/4D reconstruction of X-ray angiography data

Description

The field of 3D reconstruction from 2D imaging using deep learning is rapidly advancing. Neural Radiance Fields (NeRFs) [1] have shown great promise in this area for both natural and medical imaging. To address the slow training and inference of these models, Gaussian Splatting [2] has been introduced, reducing reconstruction times from hours to minutes.

X-ray coronary angiography, which images the coronary arteries, stands to benefit from these improvements. Some studies have explored using Gaussian Splatting for this data [3], but they rely on time-consuming segmentations, limiting clinical use. Our group recently proposed a NeRF-based method that reconstructs directly from raw dynamic X-ray angiography data without segmentation [4], though it remains too slow for clinical application. While moving from NeRFs to Gaussian Splatting would improve computational speed, no solution currently applies this technique directly to raw angiography data.

In this project, you will develop a fast method for 3D reconstruction of X-ray coronary angiography using the latest Gaussian Splatting techniques. We expect you to have a strong technical background, as you will be working with computer graphics techniques and deep learning models.


Video from [4]

[1] https://www.matthewtancik.com/nerf; Mildenhall, B., Srinivasan, P. P., Tancik, M., Barron, J. T., Ramamoorthi, R., & Ng, R. (2021). Nerf: Representing scenes as neural radiance fields for view synthesis. Communications of the ACM65(1), 99-106.

[2] https://repo-sam.inria.fr/fungraph/3d-gaussian-splatting/; Kerbl, B., Kopanas, G., Leimkühler, T., & Drettakis, G. (2023). 3D Gaussian Splatting for Real-Time Radiance Field Rendering. ACM Trans. Graph.42(4), 139-1.

[3] Fu, X. et al. (2024). 3DGR-CAR: Coronary Artery Reconstruction from Ultra-sparse 2D X-Ray Views with a 3D Gaussians Representation. In: Linguraru, M.G., et al. Medical Image Computing and Computer Assisted Intervention – MICCAI 2024. MICCAI 2024. Lecture Notes in Computer Science, vol 15007. Springer, Cham. https://doi.org/10.1007/978-3-031-72104-5_2

[4] https://kirstenmaas.github.io/nerfca/; Maas, K. W. H., Ruijters, D., Vilanova, A., & Pezzotti, N. (2024). NeRF-CA: Dynamic Reconstruction of X-ray Coronary Angiography with Extremely Sparse-views. arXiv preprint arXiv:2408.16355.

Details
Supervisor
Kirsten Maas
Secondary supervisor
Anna Vilanova
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